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Saturday, May 16, 2020 | History

5 edition of Inhibition of Polyamine Metabolism found in the catalog.

Inhibition of Polyamine Metabolism

Biological Significance and Basis for New Therapies

by Peter P. McCann

  • 258 Want to read
  • 11 Currently reading

Published by Academic Pr .
Written in English


Edition Notes

ContributionsAlbert Sjoerdsma (Editor)
The Physical Object
Number of Pages371
ID Numbers
Open LibraryOL7328158M
ISBN 100124818358
ISBN 109780124818354

In addition, polyamine blocking therapy, a strategy that combines the inhibition of polyamine biosynthesis with the simultaneous blockade of polyamine transport, can be more effective than.   Inhibition of Polyamine Metabolism. In the past decades polyamine metabolism in fungi has attracted the attention of researches worldwide with, among other aspects, the aim to manipulate it and use it as a strategy to control fungal plant diseases. The first consideration to study this promising aspect was the possibility to inhibit the.

The inhibition of polyamine biosynthesis induced by a specific and irreversible inhibitor of ornithine decarboxylase (ODC; the first key enzyme involved in polyamine biosynthesis) resulted in a depletion of brain polyamines to levels similar to those observed after allatectomy. During the same time, the mitotic rate in the proliferative area of mushroom bodies was strongly depressed to values comparable to .   The amino-acid-derived polyamines have long been associated with cell growth and cancer, and specific oncogenes and tumour-suppressor genes regulate polyamine metabolism. Inhibition of polyamine Cited by:

  The present review focuses on this aspect of the mode of action of polyamines and polyamine metabolism during biotroph and necrotroph interactions between plants and pathogens. It seems that apoplastic metabolism of polyamines of the host and the accumulation of H2O2 as a result of polyamine catabolism play important signalling role in plant. Emerging evidence shows that an aberrant polyamine metabolism is a hallmark of Hh-dependent tumors and that its pharmacological inhibition elicits relevant therapeutic effects in clinical or preclinical models of BCC and MB. We discuss here the current knowledge of polyamine metabolism, its role in cancer and the available targeting by: 2.


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Inhibition of Polyamine Metabolism by Peter P. McCann Download PDF EPUB FB2

Inhibition of Polyamine Metabolism: Biological Significance and Basis for New Therapies provides an overview of the field concerning polyamine biosynthesis inhibitors. The book is comprised of chapters which describe the compounds which are in use; the rationale for the design of such inhibitors; their synthesis and action; their biological effects on mammalian cells and tissues, plants, and.

Inhibition of Polyamine Metabolism: Biological Significance and Basis for New Therapies provides an overview of the field concerning polyamine biosynthesis Edition: 1. Book Review; Published: December ; Inhibition of polyamine metabolism.

P.P. McCann, A.E. Pegg and A. Sjoerdsma (Eds), San Diego: Academic Press Inc. xvi + pages. $ ISBN Plant Growth Regulation volume 7, pages – ()Cite this article. However, the dysregulation of polyamine metabolism is a frequent event in various pathological conditions, Inhibition of Polyamine Metabolism book cancer, inflammation, stroke, neurodegeneration, diabetes and renal failure ( The results suggest that the greater growth inhibition in P.

infestans caused by the inhibitors of polyamine metabolism may be related to the inherently smaller polyamine concentration, which probably results from the relatively low ODC activity found Cited by: 6. Cell Reports Article Inhibition of the Polyamine Synthesis Pathway Is Synthetically Lethal with Loss of Argininosuccinate Synthase 1 Matthew Locke,1,4,5 Essam Ghazaly,2,4 Marta O.

Freitas,1 Mikaella Mitsinga,1 Laura Lattanzio,3 Cristiana Lo Nigro,3 Ai Nagano,1 Jun Wang,1 Claude Chelala,1 Peter Szlosarek,1 and Sarah A. Martin1,* 1Centre for Molecular Oncology, Barts Cancer Institute, Queen. The identification of increased polyamine concentrations in a variety of diseases from cancer and psoriasis to parasitic infections has led to the hypothesis that manipulation of polyamine metabolism is a realistic target for therapeutic or preventative intervention in the treatment of certain diseases.

The early development of polyamine biosynthetic single enzyme inhibitors such as α Cited by:   Several enzymes involved in polyamine metabolism had a significant increase in expression in the ASS1-deficient Ju77S cells (Figures 4 B and 4C).

These include the rate-limiting enzyme in polyamine biosynthesis ornithine decarboxylase (ODC1), adenosylmethionine decarboxylase 1 (AMD1), spermine synthase (SMS), spermine oxidase (SMOX), and agmatinase (AGMAT ; Cited by:   Inhibition of S-adenosylmethionine decarboxylase by inhibitor SAMA connects polyamine metabolism with pMdm2-Akt/protein kinase B regulation and apoptosis in neuroblastoma.

Mol. Cancer Ther. 8, –Cited by: Additional Physical Format: Online version: Inhibition of polyamine metabolism. Orlando: Academic Press, (OCoLC) Online version: Inhibition of polyamine metabolism. Genre/Form: Electronic books: Additional Physical Format: Print version: Inhibition of polyamine metabolism.

Orlando: Academic Press, (DLC) Polyamine pathway inhibition as a novel therapeutic approach to treating “fonc” — 20 12/1 1/1 6 — — pag e1—# 1 REVIEW ARTICLE. Inhibition of Polyamine Metabolism: Biological Significance and Basis for New Therapies provides an overview of the field concerning polyamine biosynthesis book is comprised of chapters which describe the compounds which are in use.

The various effects of polyamines on growth and survival are also documented. The book details the mechanisms of polyamine homeostasis and the role of polyamine molecules as precursors of secondary metabolites such as plant alkaloids and toxins derived from spiders and wasps.

The role of polyamines in longevity and disease is discussed. Locke et al. have generated a model of ADI-PEG20 resistance in mesothelioma cells.

They reveal that ASS1-deficient cells have decreased levels of acetylated polyamine metabolites, together with a compensatory increase in expression of polyamine biosynthetic enzymes.

This elucidates a synthetic lethal interaction between ASS1 loss and inhibition of polyamine by: Bey P, Danzin C, Jung M () Inhibition of basic amino acid decarboxylases involved in polyamine biosynthesis.

In: McCann PP, Pegg AE, Sjoerdsma A (eds) Inhibition of polyamine metabolism. Biological significance and basis for new therapies.

Academic Press Inc. However, advances in our knowledge of polyamine metabolism have changed the focus of drug discovery in the polyamine area from an enzyme-inhibition strategy to a systematic search for polyamine analogs that exert antitumor effects through a variety of mechanisms, including the induction of apoptosis, inhibition of polyamine catabolism or.

In the present study, using DFMO we tested the hypothesis that inhibition of polyamine biosynthesis may protect against MCT-induced PH by limiting increases in DNA synthesis. We injected rats with MCT (60 mg kg) or % NaCl and measured DNA synthesis 7 days after MCT by determining [ 3 H]thymidine incorporation into whole lung by: The development of polyamine transport inhibitors (PTIs), in combination with the polyamine biosynthesis inhibitor difluoromethylornithine (DFMO), provides a method to target cancers with high polyamine requirements.

The DFMO+PTI combination therapy results in sustained intracellular polyamine depletion and cell death. A series of substituted benzene derivatives were evaluated for. POLYAMINE BIOSYNTHESIS. The first rate-limiting enzyme in the polyamine pathway is ornithine decarboxylase (ODC1), which catalyzes the decarboxylation and conversion of ornithine, a product of the urea cycle, to the primary polyamine putrescine (Pegg, ).Cited by:.

Inhibitors of polyamine biosynthesis and inducers of their catabolism have been evaluated as antitumor drugs, however, their efficacy and safety remain controversial. Our goal was to investigate if drug-induced modulation of polyamine metabolism plays a role in dedifferentiation using differentiated human hepatocyte-like HepaRG cell cultures.Polyamine metabolism in carcinoma of the oral cavity compared with adjacent and normal oral mucosa The American Journal of Surgery, Vol.No.

4 Plasmodium falciparum and Plasmodium berghei: Effects of ornithine decarboxylase inhibitors on erythrocytic schizogony. A phase I and pharmacokinetic study of SAMA, a novel polyamine biosynthesis inhibitor, administered on a daily‐times‐five every‐three‐week schedule in patients with advanced solid malignancies, by: